Structural Biology II: Structure and function relationships in biological macromolecules (StrBio2)7.5 ECTS
(englische Bezeichnung: Strukturbiologie II: Struktur-Funktionsbeziehungen in Biologischen Makromolekülen)
(Prüfungsordnungsmodul: Structural Biology II: Structure und Function Relationships in Biotechnologically Relevant Macromolecules)

Lehrveranstaltungen:

• • Mastermodul Biotechnik II: Structure und function relationships in biotechnologically relevant macromolecules
    (Übung, 6 SWS, Yves Muller, Einzeltermine am 4.4.2017, 9:15 - 10:45, Seminarraum ZMPT; 5.4.2017, 9:15 - 10:15, Hörsaal ZMPT; 6.4.2017, 9:15 - 10:45, Hörsaal ZMPT; 7.4.2017, 9:15 - 10:15, Hörsaal ZMPT; 10.4.2017, 11.4.2017, 9:15 - 10:45, Hörsaal ZMPT; 12.4.2017, 13.4.2017, 9:15 - 10:45, SR Biologie; 18.4.2017, 9:15 - 10:00, Hörsaal ZMPT; 19.4.2017, 9:15 - 10:45, Hörsaal ZMPT; 20.4.2017, 9:15 - 10:00, Hörsaal ZMPT; 24.4.2017, 9:15 - 12:00, SR Biologie; 27.4.2017, 13:15 - 14:45, SR Biologie; vom 4.4.2017 bis zum 28.4.2017; Weitere Details zum Programm werden während der Veranstaltung bekannt gegeben.)

Empfohlene Voraussetzungen:

none

Inhalt:

Seminar talks cover theoretical and methodological approaches for the study of structure-function relationships in proteins with a focus on structural determinants in regulation of protein function.

Laboratory course are focused on advanced methods in the study of structure-dynamics-function relationships of proteins. Both experimental (heterologous protein production in eucaryotic cells, X-ray analysis, mutation studies) as well as theoretical methods (atomistic and coarse-grained molecular dynamics simulations) will be addressed.

The main part of the practical course is devoted to active cooperation in ongoing research projects of the participating labs.

Lernziele und Kompetenzen:

The students are

• acquainted with novel insights, concepts, and methods in the study of protein-dynamics-function relationships

• understand state-of-the-art methods in the analysis of protein structure, dynamics, function and their limitations

• are able to independently develop working hypotheses, to independently design and conduct experiments

• able to present and critically discuss current research articles / their results and defend their conclusions in proper context
  

Literatur:

introductory articles will be provided electronically

Verwendbarkeit des Moduls / Einpassung in den Musterstudienplan:

1. 643#65#H
   (Po-Vers. 2012 | NatFak | Integrated Life Sciences: Biologie, Biomathematik, Biophysik (Master of Science) | Modulgruppen | MG1: Mathematische Modellierung und Systembiologie | Wahlpflichtmodule der Modulgruppe1 | Structural Biology II: Structure und Function Relationships in Biotechnologically Relevant Macromolecules)
2. 643#65#H
   (Po-Vers. 2012 | NatFak | Integrated Life Sciences: Biologie, Biomathematik, Biophysik (Master of Science) | Modulgruppen | MG2: Bioimaging und Biophysik | Wahlpflichtmodule der Modulgruppe2 | Structural Biology II: Structure und Function Relationships in Biotechnologically Relevant Macromolecules)
3. 643#65#H
   (Po-Vers. 2012 | NatFak | Integrated Life Sciences: Biologie, Biomathematik, Biophysik (Master of Science) | Modulgruppen | MG3: Biologische Strukturen und Prozesse | Wahlpflichtmodule der Modulgruppe3 | Structural Biology II: Structure und Function Relationships in Biotechnologically Relevant Macromolecules)

Studien-/Prüfungsleistungen:

Portfolio exam Structural Biology II: Structure and Function Relationships in Biotechnologically Relevant Macromolecules (Prüfungsnummer: 22111)

Prüfungsleistung, mehrteilige Prüfung, benotet, 7.5 ECTS

Anteil an der Berechnung der Modulnote: 100.0 %

weitere Erläuterungen:
PL: mündliche Prüfung 30 Min. PL: mündliches Referat PL: schriftliches Protokoll

Erstablegung: SS 2017

1. Prüfer:

Böckmann/Muller