| Contractile forces during cancer cell migration in a 3-D connective tissue matrix The general aim of this project is to characterize the mechanical forces that cancer cells generate during their migration through a connective tissue matrix. We propose two specific aims. The first aim is to develop a method for measuring the tractions that single cells exert on their surroundings during migration in a connective tissue matrix. The second aim is to test the hypothesis that cancer cell migration through a 3-D tissue matrix is augmented by the ability to generate higher forces, or put differently, that more invasive tumor cells generate higher traction forces. | Projektleitung:
Prof. Dr. Ben Fabry
Beteiligte:
Dr. rer. nat. Claudia Mierke, James P. Butler
Laufzeit: 1.1.2008 - 31.12.2009
Förderer:
Deutsche Forschungsgemeinschaft
Mitwirkende Institutionen:
Harvard University, Harvard School of Public Health
Kontakt:
Fabry, Ben
Telefon +49 9131 85-25610, Fax +49 9131 85-25601, E-Mail: ben.fabry@fau.de
| | Publikationen |
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| Mierke, Claudia ; Paranhos Zitterbart, Daniel ; Kollmannsberger, Philip ; Raupach, Carina ; Schlötzer-Schrehardt, Ursula ; Goecke, Tamme ; Behrens, Jürgen ; Fabry, Ben: Breakdown of the Endothelial Barrier Function in Tumor Cell Transmigration. In: Biophysical Journal (2007), S. 1-32 | | Bauer, Katja ; Mierke, Claudia ; Behrens, Jürgen: Expression profiling reveals genes associated with transendothelial migration of tumor cells: a functional role for alphavbeta3 integrin. In: International Journal of Cancer (2007), S. 1-34 | Mierke, Claudia ; Kollmannsberger, Philip ; Paranhos Zitterbart, Daniel ; Smith, James ; Fabry, Ben ; Goldmann, Wolfgang: Mechano-coupling and regulation of contractility by the vinculin tail domain. In: Biophysical Journal (2007), S. 1-28
[doi>10.1529/biophysj.107.108472] | Metzner, Claus ; Raupach, Carina ; Paranhos Zitterbart, Daniel ; Fabry, Ben: Simple model of cytoskeletal fluctuations. In: Physical Review E 76 (2007), S. 1-12
[doi>10.1103/PhysRevE.76.021925] | Raupach, Carina ; Paranhos Zitterbart, Daniel ; Mierke, Claudia ; Metzner, Claus ; Müller, Frank ; Fabry, Ben: Stress fluctuations and motion of cytoskeletal-bound markers. In: Physical Review E 76 (2007), S. 1-12
[doi>10.1103/PhysRevE.76.011918] |
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